Evaluation of Podoplanin in Oral Leukoplakia and Oral Squamous Cell Carcinoma

نویسندگان

  • Ashok Patil
  • Kishor Patil
  • Suyog Tupsakhare
  • Mahesh Gabhane
  • Shrikant Sonune
  • Shilpa Kandalgaonkar
چکیده

Background. Recent studies have demonstrated that podoplanin was expressed in some dysplastic lesions adjacent to primary oral cancers suggesting that podoplanin expression may occur in early oral tumorigenesis and lymphangiogenesis and therefore is related to tumor growth. The purpose of this study is to determine the role of podoplanin as a biomarker for cancer risk assessment in oral leukoplakia and correlation of podoplanin expression with grades of oral squamous cell carcinoma (OSCC). Materials and Methods. In the present retrospective study, podoplanin expression was investigated immunohistochemically in 40 patients each of oral leukoplakia and OSCC. The scores were analyzed statistically using one-way ANOVA test followed by Tukey HSD. Results. By applying one-way ANOVA test, there was a highly significant increase of the podoplanin expression from mild to severe dysplasia and from well to poorly differentiated OSCC (P < 0.01). Statistically highly significant difference was present between scores of mild to moderate dysplasia, moderate to severe dysplasia, well to poorly differentiated OSCC, and moderately to poorly differentiated OSCC (Tukey HSD test, P < 0.01). Conclusion. Podoplanin can be used as a biomarker for early oral tumorigenesis and for malignant transformation risk assessment of premalignant lesions and as a tumor progression biomarker for advanced grades of OSCC.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Podoplanin expression in oral potentially malignant disorders and oral squamous cell carcinoma

Background Podoplanin is a type I transmembrane sialomucin-like glycoprotein that is specifically expressed in lymphatic endothelial cells. Studies have shown that assessment of podoplanin expression in the epithelial cells can be used to predict the malignant transformation of potentially malignant disorders and the metastatic tendency of primary head and neck squamous cell carcinoma. The aim ...

متن کامل

Comparing Immunohistochemical Expression of Podoplanin between Oral Squamous Cell Carcinoma and Normal Oral Mucosa

Background and purpose: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer in the world. Podoplanin is a mucin-like integral membrane glycoprotein that is expressed in the lymphatic endothelial cells but not in the blood vascular endothelial cells. The aim of the present study was to investigate the immunohistochemical expression of podoplanin and evaluating lymphangiogenesis i...

متن کامل

The Expression of P53 in Leukoplakia, Squamous Cell Carcinoma and Normal Oral Epithelium Using Immunohistochemical Staining Method

Background & Aims: Leukoplakia is the most common premalignant or potentially malignant lesion of the oral mucosa and its potentiality for malignant transformation is unpredictable. The aim of the present study was to evaluate p53 expression in normal oral epithelium, leukoplakia and oral squamous cell carcinoma. Methods: The standard Biotin streptavaidin peroxidase immunohistochemical staining...

متن کامل

Detection of Apoptosis in Leukoplakia and Oral Squamous Cell Carcinoma using Methyl Green Pyronin and Hematoxylin and Eosin

Background & Objective: Cell population and turnover are controlled by a balance between cell proliferation and apoptosis. Detection of apoptosis in oral cancer contributes to its better prognosis and improved management. This study aimed to quantify apoptotic cells in leukoplakia and oral squamous cell carcinoma (OSCC) using methyl green-pyronin (MGP) and hematoxylin and eosin...

متن کامل

Diagnosis Prediction of Lichen Planus, Leukoplakia and Oral Squamous Cell Carcinoma by using an Intelligent System Based on Artificial Neural Networks

Introduction: Diagnosis, prediction and control of oral lesions is usually done classically based on clinical signs and histopathologic features. Due to lack of timely diagnosis in all conventional methods or differential diagnosis, biopsy of patient is needed. Therefore, the patient might be irritated. So, an intelligent method for quick and accurate diagnosis would be crucial. Intelligent sys...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 2015  شماره 

صفحات  -

تاریخ انتشار 2015